Key result
Addition of CaMK II with ATP and calmodulin dramatically increased the sensitivity of a novel bovine tracheal anion channel to free Ca2+, shifting activation to lower intracellular calcium levels.
Population
Bovine tracheal apical membrane vesicles (in vitro model)
Comparison
Ca2+/calmodulin protein kinase II in the… vs Absence of kinase, ATP, or calmodulin; or…
Design
Preclinical
Authors
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Should not change clinical practice; leaves open CaMK II's role in human airway epithelial ion transport.
A novel Ca2+-sensitive anion channel isolated from bovine airway epithelium is regulated by CaMK II phosphorylation, increasing its sensitivity to physiological calcium levels.
Fuller et al. (1994) studied this question. Ca2+/calmodulin protein kinase II (CaMK II) vs. Absence of kinase, ATP, or calmodulin; protein kinase A was evaluated on Channel open probability (Po) and sensitivity to free Ca2+. Addition of CaMK II with ATP and calmodulin dramatically increased the sensitivity of a novel bovine tracheal anion channel to free Ca2+, shifting activation to lower intracellular calcium levels.
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