Key result
ATP (500 microM) significantly augmented KCa channel activity in equine tracheal myocytes, increasing open-state probability from 0.010 to 0.034.
Absolute Event Rate: 0.034% vs 0.01%
ATP augments KCa channel activity in equine tracheal myocytes through phosphorylation catalyzed by endogenous PKA, which requires anchoring via AKAP.
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Endogenous PKA activates KCa channels in airway myocytes; extends basic mechanisms but leaves open clinical translation.
Wang et al. (1996) studied this question. ATP vs. Baseline (absence of exogenous protein kinases) was evaluated on KCa channel activity (open-state probability, nPo). ATP (500 microM) significantly augmented KCa channel activity in equine tracheal myocytes, increasing open-state probability from 0.010 to 0.034.