Why the study?
The Heart Failure Association updated its 2007 definition of advanced chronic heart failure to emphasize the role of comorbidities, tachyarrhythmias, and heart failure with preserved ejection fraction.
The 2018 update to the Heart Failure Association definition of advanced heart failure incorporates modern considerations such as HFpEF, comorbidities, and advances in mechanical circulatory support.
Informs contemporary advanced HF management and trial eligibility; extends prior definitions to include HFpEF and MCS advances.
The clinical course of heart failure is characterised by progressive worsening of cardiac function and symptoms. Patients progress to a condition where traditional treatment is no longer effective and advanced therapies, such as mechanical circulatory support, heart transplantation and/or palliative care, are needed. This condition is called advanced chronic heart failure. The Heart Failure Association first defined it in 2007 and this definition was updated in 2018. The updated version emphasises the role of comorbidities, including tachyarrhythmias, and the role of heart failure with preserved ejection fraction. Improvements in mechanical circulatory support technology and better disease management programmes are major advances and are radically changing the management of these patients.
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Metra et al. (2019) conducted a review in Advanced chronic heart failure. The 2018 updated Heart Failure Association definition of advanced heart failure emphasizes the role of comorbidities, heart failure with preserved ejection fraction, and mechanical circulatory support.