Aiming at the enhancement of total lethal effect of radiations, chemical agent actions on irradiated cells were investigated. It was found that the sensitivity of irradiated cells to NaCI was markedly increased by radiation. In other words, the over-all lethal effect of radiations on micro organisms was enhanced by the pre-or post-treatment with NaCI. Some microbiological aspects of radiation enhancement of NaCI sensitivity were described in this paper, connecting with the possible mechanism. The fact that this phenomenon of radiation enhancement was observed in the case of the cells which gave the one-hit type survival curve suggests that radiation damage responsible for this phenomenon is not restricted to biological targets . Further discussion and experimental evidences will be presented in the subsequent paper .
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Okazawa et al. (1960) studied this question.