Key result
A novel common variant at the INSR locus was significantly associated with lower diastolic blood pressure (beta -0.29; P=7.28x10^-23) in a large-scale meta-analysis.
Why the study?
The availability of whole-genome sequencing data in large studies enabled the assessment of coding and noncoding variants across the allele frequency spectrum for associations with blood pressure.
Population
51 456 stage-1 participants plus stage-2 cohorts of up to 383 145 participants
Comparison
Coding and noncoding genetic variants across the allele frequency spectrum
Design
Multiancestry whole-genome sequencing analysis with stage-2 array and whole-exome sequencing meta-analyses
Authors
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No immediate change to hypertension management; extends genetic architecture of blood pressure at INSR.
Observational (n=764,135)
Yes
Mean Difference: -0.29
p-value: p=7.28×10^-23
Large-scale whole-genome sequencing identified a novel common variant at the INSR locus associated with diastolic blood pressure, highlighting the utility of aggregate analyses in genetic studies of hypertension.
Kelly et al. (2022) conducted an observational in Blood pressure and hypertension (n=764,135). Genetic variants (whole-genome sequencing) was evaluated on Systolic and diastolic blood pressure (beta -0.29, p=7.28×10^-23). A novel common variant at the INSR locus was significantly associated with lower diastolic blood pressure (beta -0.29; P=7.28x10^-23) in a large-scale meta-analysis.
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