What is the clinical evidence from this study?

Study design: Observational. Population: Chronic renal failure (n=25). Intervention: Haemodialysis. Primary outcome: Clinically significant arrhythmias (>100 ventricular extrasystoles/24 h).

What question did this study set out to answer?

To assess the frequency and clinical significance of cardiac arrhythmias during haemodialysis and interdialytic periods in patients with chronic renal failure.

December 4, 2008The Nephron journals/Nephron journals

Cardiac Arrhythmias in Chronic Renal Failure?

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Key result

Haemodialysis with a low dialysate potassium concentration was associated with clinically significant arrhythmias in only 4% (1 of 25) of patients with chronic renal failure.

Why the study?

What is the prevalence and type of cardiac arrhythmias during haemodialysis with low dialysate potassium in patients with chronic renal failure?

Population

25 patients undergoing regular haemodialysis for chronic renal failure

Design

Cohort

Follow-up

48 hours

Authors

MKMichael KyriakidisNational and Kapodistrian University of Athens SVS. Voudiclaris DKDimitris Th Kremastinos

Discussion

Member takes

Implication

Low dialysate potassium haemodialysis linked to few arrhythmias in this small cohort; hypothesis-generating and leaves open need for randomized confirmation.

Key Points

To assess the frequency and clinical significance of cardiac arrhythmias during haemodialysis and interdialytic periods in patients with chronic renal failure.
Monitored N=25 patients with chronic renal failure undergoing regular haemodialysis.
Conducted continuous 48-hour Holter ECG monitoring spanning the active dialysis session and normal activities at home using a low dialysate potassium concentration (1.7 mEq/l).
Clinically significant arrhythmias (>100 ventricular extrasystoles per 24 hours) occurred in only 1 patient (4%), with no complex ventricular arrhythmias observed.
Benign atrial arrhythmias were recorded in 22 patients (88%).
Haemodialysis sessions had no measurable influence on the type or frequency of cardiac arrhythmias.

Study Design

Type

Observational (n=25)

Structured PICO

What is the prevalence and type of cardiac arrhythmias during haemodialysis with low dialysate potassium in patients with chronic renal failure?

Population

25 patients undergoing regular haemodialysis for chronic renal failure monitored with 48-hour Holter ECG.

Exposure

Haemodialysis using a low dialysate potassium concentration (1.7 mEq/l) with continuous 48-hour Holter ECG monitoring

Outcome

Frequency and type of cardiac arrhythmias (clinically significant ventricular arrhythmias, complex ventricular arrhythmias, and benign atrial arrhythmias)surrogate

Haemodialysis with a low dialysate potassium concentration does not appear to induce complex ventricular arrhythmias or influence arrhythmia frequency in patients with chronic renal failure.

Cite This Study

Kyriakidis et al. (2008) conducted an observational in Chronic renal failure (n=25). Haemodialysis was evaluated on Clinically significant arrhythmias (>100 ventricular extrasystoles/24 h). Haemodialysis with a low dialysate potassium concentration was associated with clinically significant arrhythmias in only 4% (1 of 25) of patients with chronic renal failure.

synapsesocial.com/papers/6a9ebafbd4f4c5237ab285f0 https://doi.org/10.1159/000183273

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Implication

Low dialysate potassium haemodialysis linked to few arrhythmias in this small cohort; hypothesis-generating and leaves open need for randomized confirmation.

Cardiac Arrhythmias in Chronic Renal Failure?

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Cardiac Arrhythmias in Chronic Renal Failure?

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider