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Double duty: Dimeric aminoglycoside antibiotics were designed by linking neamine or nebramine cores with various tethers differing in length and composition. The resulting dimeric aminoglycosides displayed high affinity for the 16S A site of ribosomal RNA (a representation of the complex is shown here) and were effective against various aminoglycoside-resistant bacterial strains.
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Agnelli et al. (2004) studied this question.
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