Key result
Isoprinosine administered at 6 g daily for 7 days did not significantly alter clinical symptoms, virus shedding, or serological responses compared to placebo in volunteers experimentally infected with rhinovirus.
Why the study?
Does isoprinosine improve clinical picture or reduce virus shedding in volunteers inoculated with rhinovirus?
Population
n=45 volunteers inoculated intranasally with both rhinovirus type 9 and rhinovirus type 31
Comparison
Isoprinosine 6 g orally daily for 7 days vs Placebo
Design
Other
Authors
Loading...
Isoprinosine shows no benefit in experimental rhinovirus; leaves open its potential in natural infections or other viruses.
RCT (n=45)
Double-blind
No
Does isoprinosine improve clinical picture or reduce virus shedding in volunteers inoculated with rhinovirus?
Absolute Event Rate: 14% vs 14%
Isoprinosine at 6 g daily for 7 days does not demonstrate useful antiviral activity against rhinovirus infection in volunteers.
Soto et al. (1973) conducted an RCT in Rhinovirus infection (n=45). Isoprinosine vs. Placebo was evaluated on Average clinical score. Isoprinosine administered at 6 g daily for 7 days did not significantly alter clinical symptoms, virus shedding, or serological responses compared to placebo in volunteers experimentally infected with rhinovirus.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: