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March 4, 2022Scientific ReportsOpen Access

fMRI-based validation of continuous-wave fNIRS of supplementary motor area activation during motor execution and motor imagery

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Key result

Continuous-wave fNIRS reliably captured supplementary motor area activation during motor execution and motor imagery, demonstrating spatial specificity and task sensitivity comparable to fMRI.

Why the study?

Neurofeedback applications require that functional near infrared spectroscopy can measure signals from the target brain region of interest, such as the supplementary motor area.

Can continuous-wave fNIRS reliably measure supplementary motor area activation during motor execution and motor imagery compared to fMRI in healthy older adults?

Population

16 healthy older participants

Comparison

Continuous-wave fNIRS vs fMRI across executed and imagined motor tasks

Design

Validation study with separate fNIRS and fMRI sessions

Authors

FKFranziska KleinSDStefan DebenerKWKarsten Witt

Discussion

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Overview

Supports portable fNIRS for motor imagery research in older adults; leaves open clinical neurofeedback use pending patient validation.

Study Design

Type

Cross-Sectional (n=16)

Multicenter

No

Structured PICO

Can continuous-wave fNIRS reliably measure supplementary motor area activation during motor execution and motor imagery compared to fMRI in healthy older adults?

P
Population
16 healthy older adults (mean age 64 years) completed separate fNIRS and fMRI sessions to validate fNIRS measurement of supplementary motor area activation during motor execution and imagery.
E
Exposure
Continuous-wave functional near-infrared spectroscopy (CW-fNIRS) during motor execution and motor imagery tasks.
C
Comparator
Functional magnetic resonance imaging (fMRI) during the same tasks.
O
Outcome
Spatial specificity and task sensitivity of supplementary motor area (SMA) activation.surrogate

Continuous-wave fNIRS is a valid tool for measuring supplementary motor area activation during motor imagery, supporting its potential use in neurofeedback applications.

Limitations

  • fNIRS and fMRI were recorded consecutively, not concurrently
  • Inaccuracies in optical digitizer position tracking due to narrow camera field of view
  • Filter settings may not have accounted for very low frequency oscillations
  • Analyses were restricted to HbO and HbR signals, excluding total hemoglobin

Cite This Study

Klein et al. (2022) conducted a cross-sectional in Healthy older adults (n=16). Continuous-wave fNIRS vs. fMRI was evaluated on Spatial specificity and task sensitivity of SMA activation. Continuous-wave fNIRS reliably captured supplementary motor area activation during motor execution and motor imagery, demonstrating spatial specificity and task sensitivity comparable to fMRI.

synapsesocial.com/papers/6a9ec1c19fb28041eca5365ahttps://doi.org/10.1038/s41598-022-06519-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Can time-resolved NIRS provide the sensitivity to detect brain activity during motor imagery consistently?2017 · 53 citations
  2. 2Review of functional near-infrared spectroscopy in neurorehabilitation2016 · 127 citations
  3. 3Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy?2003 · 176 citations
  4. 4Simultaneous Recording of Cerebral Blood Oxygenation Changes during Human Brain Activation by Magnetic Resonance Imaging and Near-Infrared Spectroscopy1996 · 460 citations
  5. 5Surface Electromyography Signal Processing and Classification Techniques2013 · 1,007 citations