Key result
Atrial fibrillation during pregnancy was associated with significantly higher rates of uterine rupture (37.5% vs 2.6%), abortion (50% vs 17.4%), and post-partum hemorrhage (37.5% vs 5.3%) (p<0.05).
Why the study?
AF is associated with numerous morbidities and mortalities, and pregnant women are at higher risk of developing AF, but maternal and fetal complications in this population needed evaluation.
Does atrial fibrillation during pregnancy increase the risk of maternal and fetal complications compared to pregnant women without atrial fibrillation?
Cohort
Yes
Does atrial fibrillation during pregnancy increase the risk of maternal and fetal complications compared to pregnant women without atrial fibrillation?
p-value: p=<0.05
Pregnant women who develop atrial fibrillation are at significantly higher risk for severe maternal complications including uterine rupture, abortion, and post-partum hemorrhage.
AF in pregnancy signals higher maternal complication risk; Level 3 data leaves open causality and should not yet change practice.
Background: Atrial fibrillation (AF) has been associated with numerous morbidities and mortalities. Pregnant women are at higher risk to develop AF.Objective: This study aims at investigating the maternal and fetal complications in women who developed AF during pregnancy compared to a control group.Patients and Methods: A prospective study was conducted on 2 groups; women with AF and women without AF. The included women were recruited from Beni-Suef University Hospital and Beni-Suef General Hospital after obtaining their informed consents. The maternal and fetal complications have been reported and compared between both groups.Results: The rates of placental complications, vaginal hematoma, congenital anomalies and the need for neonatal ICU were relatively higher amongst women with AF than those without AF but no statistically significant differences have been noticed (p>0.05). Rupture uterus, abortion and post-partum hemorrhage were statistically higher amongst women with AF in comparison to women without AF; 37.5% versus 2.6%, 50% versus 17.4%, and 37.5% versus 5.3%, respectively (p<0.05). Warfarin, Metoprolol and Digoxin were the most commonly reported medications amongst women with AF. The prescribed medications did not affect the likelihood of maternal or fetal complications (p>0.05).Conclusion: Women who develop AF during pregnancy are more likely to develop maternal complications.
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Khamis et al. (2019) conducted a cohort in Atrial fibrillation during pregnancy. Atrial fibrillation vs. No atrial fibrillation was evaluated on Maternal and fetal complications (p=<0.05). Atrial fibrillation during pregnancy was associated with significantly higher rates of uterine rupture (37.5% vs 2.6%), abortion (50% vs 17.4%), and post-partum hemorrhage (37.5% vs 5.3%) (p<0.05).
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