Inflammatory Markers in Acute Ischaemic Stroke in Relation to Clinical Severity and Early Outcome

BACKGROUND markers of inflammation could be useful to predict severity of stroke in acute phase. Stroke is the third cause of and the first cause of disability. Recent literature have demonstrated that inflammation contributes to all phases of . The results of researchers suggest that atherosclerosis is an inflammatory disease. aim of the study is to assess the1. of peripheral inflammatory markers in acute ischaemic stroke and their relation to severity of acute stroke. 2. Value of inflammatory markers in predicting the short-term outcome and disability at the end of six months. AND METHODS is a prospective case control study for 6 months done from September 2014 to August 2016 in 100 patients of acute stroke within first 5 days of symptom onset in comparison >18 years of age with 50 age and sex matched controls. samples for all cases and controls were sent for erythrocyte sedimentation rate, Neutrophil-to-Lymphocyte Ratio (NLR), -C-reactive protein, mean platelet volume, serum ferritin, serum albumin and S. gamma-glutamyl transferase at admission. mean values of ESR, NLR, hs-CRP in all the cases are higher when compared to the controls and are statistically significant, the mean values of MPV, S. ferritin, S. albumin and GGT in cases are lower when compared to controls, but are within range and difference is statistically significant except ferritin. ESR, hs-CRP has significant correlation with severity of ischaemic stroke. The mean values of these markers increased with increase in severity. Serum albumin has significant with severity of acute ischaemic stroke with mean values of these markers decreasing with increase in severity of . There is no significant correlation of the inflammatory markers in present study with the short-term outcome. plays an important role in the pathogenesis of non-cardioembolic ischaemic stroke. Management of acute stroke in relation to inflammatory markers need to be well elucidated by further long-term study.