Key result
Sequential cholesterol embolization over a prolonged period can compromise circulation to the gastrointestinal tract, causing ischemic necrosis and cecal gangrene.
Case Report (n=1)
Highlights that sequential cholesterol embolization can lead to ischemic necrosis and gangrene of the gastrointestinal tract.
Alerts clinicians to rare GI ischemia etiologies; extends sparse case literature but leaves open prospective validation.
Cecal gangrene due to sequential cholesterol emboli occurred. The patient described demonstrated several other reported clinical manifestations of cholesterol embolization, ie, hypertension, renal failure, and gastrointestinal hemorrhage. An isolated occurrence of cholesterol embolization may pathologically result in congestion of villi, mucosal petechiae or infarcts, minute hemorrhage and hemorrhagic erosions within the gastrointestinal tract. However, the sequential occurrence of emboli over a prolonged period of time can eventually compromise the circulation to a segment of the gastrointestinal tract causing ischemic necrosis.
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Nino Carnevale (1973) conducted a case report in Cecal gangrene due to cholesterol emboli (n=1). Sequential cholesterol emboli was evaluated on Cecal gangrene and ischemic necrosis. Sequential cholesterol embolization over a prolonged period can compromise circulation to the gastrointestinal tract, causing ischemic necrosis and cecal gangrene.
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