Key result
Preventive medication with instenon (n=11) prevented or significantly reduced the deterioration of cerebral hemodynamics and neuropsychological status compared to controls after CABG.
Why the study?
Does instenon prevent cerebral perfusion deterioration and cognitive dysfunction in patients undergoing CABG with CPB?
Observational (n=30)
Does instenon prevent cerebral perfusion deterioration and cognitive dysfunction in patients undergoing CABG with CPB?
Instenon may prevent or reduce cerebral hemodynamic and neuropsychological deterioration after CABG with cardiopulmonary bypass, as effectively evaluated by 99mTc-HMPAO tomoscintigraphy.
Answers are grounded in this paper and cite their sources.
Instenon may preserve cerebral hemodynamics after CABG; hypothesis-generating and requires randomized confirmation before practice change.
The purpose of this study is to research the use of the radiopharmaceutical99mTc-HMPAO in the evaluation of drug prevention of cerebral complications in patients with coronary heart disease after coronary artery bypass grafting (CABG) performed with cardiopulmonary bypass (CPB). The study included 30 patients, in whom surgical revascularization was performed with CPB. 11 patients in this group were prescribed instenon. All the patients underwent brain tomoscintigraphy with99mTc-HMPAO and neuropsychological testing before CABG and 10-15 days after it. The results showed that99mTc-HMPAO is useful radiopharmaceutical for evaluation of cerebral complications in patients after CABG. Thus, coronary artery bypass grafting using CPB can be complicated by the deterioration of cerebral perfusion and cognitive dysfunction, while preventive medication with instenon can prevent or significantly reduce the violations of cerebral hemodynamics and neuropsychological status of the patients.
No takes yet. Share an insight, caveat, or question.
Efimova et al. (2015) conducted an observational in Coronary heart disease after coronary artery bypass grafting (CABG) (n=30). Instenon vs. No instenon was evaluated on Cerebral perfusion and cognitive dysfunction (evaluated by 99mTc-HMPAO tomoscintigraphy and neuropsychological testing). Preventive medication with instenon (n=11) prevented or significantly reduced the deterioration of cerebral hemodynamics and neuropsychological status compared to controls after CABG.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: