Key result
Brain SPECT with 99mTc-HMPAO revealed early cognitive deficit in 96% of post-CABG patients, persisting in 55% at 6 months, and correlated temporal lobe perfusion decrease with memory deterioration.
Why the study?
Does brain SPECT with 99mTc-HMPAO estimate the long-term prognosis of neurocognitive deficits in patients after CABG?
Cohort (n=22)
Does brain SPECT with 99mTc-HMPAO estimate the long-term prognosis of neurocognitive deficits in patients after CABG?
Answers are grounded in this paper and cite their sources.
Brain SPECT with 99mTc-HMPAO may be a useful tool for evaluating the long-term prognosis of neurocognitive deficits following CABG.
The aim of this work was to investigate the possibility of using brain SPECT with 99mTc-HMPAO to estimate long-term prognosis of the development of neurocognitive deficits in patients after coronary artery bypass graft (CABG). The study included 22 patients with coronary artery disease who underwent a standard estimate of neurological status, 99mTc-HMPAO brain SPECT and neuropsychological testing before CABG, 14 days and 6 months after surgical intervention. The results showed that 99mTc-HMPAO is useful radiopharmaceutical for evaluation of long-term prognosis of the development of neurocognitive deficits in patients after CABG. Thus, in 96% of patients after CABG one could observe the early cognitive deficit, which persisted in 55% of cases after 6 months. At that, a correlation between the deterioration of long-term memory after 6 months and a decrease in perfusion in the temporal lobes was detected in the early postoperative period.
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Efimova et al. (2015) conducted a cohort in coronary artery disease (n=22). 99mTc-HMPAO brain SPECT was evaluated on development of neurocognitive deficits. Brain SPECT with 99mTc-HMPAO revealed early cognitive deficit in 96% of post-CABG patients, persisting in 55% at 6 months, and correlated temporal lobe perfusion decrease with memory deterioration.
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