Key result
In patients with chronic heart failure, body mass index demonstrated an independent inverse association with plasma concentrations of NT-proBNP (β = -0.32) and adiponectin (β = -0.39).
Cross-Sectional (n=171)
No
Effect estimate: β = -0.32 for NT-proBNP; β = -0.39 for adiponectin
p-value: p=<0.001
In patients with chronic heart failure, lower BMI is independently associated with higher levels of NT-proBNP and adiponectin, suggesting a potential role of these biomarkers in the wasting process.
Lower BMI linked to higher NT-proBNP/adiponectin in chronic HF; hypothesis-generating for wasting biomarkers, no practice change from cross-sectional data.
BACKGROUND: Low body mass index (BMI) is associated with a poor outcome in chronic heart failure (CHF). An inverse association between BMI and adiponectin and N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been reported. The aim of the present study was to investigate whether novel markers of neurohormonal activation, inflammation, and endothelial dysfunction are associated with BMI in CHF. METHODS: In a cross-sectional study including 171 patients with CHF and a left ventricular ejection fraction (LVEF) ≤45% the impact of BMI on circulating plasma concentrations of adiponectin, α-defensins, high sensitivity C-reactive protein (hsCRP), copeptin, mid-regional pro-adrenomedullin (MR-proADM), NT-proBNP, and mid-regional pro-A-type natriuretic peptide (MR-proANP) were evaluated. RESULTS: In multivariable linear regression analysis including age, sex, LVEF, New York Heart Association functional classification (NYHA), estimated glomerular filtration rate (eGFR), and diabetes, only NT-proBNP (β = -0.32) and adiponectin (β = -0.39) remained independently associated with BMI. MR-proANP was associated with BMI but adjusting for age attenuated the relation being no longer significant. CONCLUSIONS: Among biomarkers typically increased in patients with CHF only adiponectin and NT-proBNP demonstrated independent inverse associations with BMI. This indicates a direct effect of these two biomarkers enhancing the wasting process seen in CHF.
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Christensen et al. (2013) conducted a cross-sectional in Chronic heart failure (n=171). Body mass index (BMI) was evaluated on Independent association of BMI with plasma biomarkers in multivariable linear regression (β = -0.32 for NT-proBNP; β = -0.39 for adiponectin, p=<0.001). In patients with chronic heart failure, body mass index demonstrated an independent inverse association with plasma concentrations of NT-proBNP (β = -0.32) and adiponectin (β = -0.39).
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