Key result
Ovarian follicular fluid contained detectable ANP immunoreactivity (3.3-60.1 pg/ml), but follicular ANP and progesterone concentrations were not significantly correlated.
Observational
ANP is detectable in human ovarian follicular fluid, suggesting the ovary may be a site of ANP secretion, though its relationship with progesterone remains unclear.
ANP detectable in follicular fluid without progesterone correlation; leaves open any ovarian regulatory role for prospective study.
Synthesis and secretion of atrial natriuretic peptide (ANP) is not confined to the heart, but also present in other tissues. ANP is known to affect steroidogenesis in the ovary. To assess the possibilities that (a) the human ovary is a source of ANP secretion as well, and (b) ovarian ANP stimulates progesterone secretion, we investigated ANP as well as progesterone concentrations in preovulatory ovarian follicular fluid form women in an in vitro fertilization program. In all women detectable ANP immunoreactivity was found in ovarian follicular fluid (range 3.3-60.1 pg/ml). Follicular fluid concentrations were low in all but 1 women who demonstrated a higher ANP level in follicular fluid than in plasma. Follicular ANP and progesterone concentrations were not significantly correlated. These preliminary results suggest that the ovary could well be a site of ANP secretion. If and how ovarian ANP activity affects progesterone secretion remains as yet unknown.
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Steegers et al. (2010) conducted an observational in In vitro fertilization. Ovarian follicular fluid ANP concentration was evaluated on Correlation between follicular ANP and progesterone concentrations. Ovarian follicular fluid contained detectable ANP immunoreactivity (3.3-60.1 pg/ml), but follicular ANP and progesterone concentrations were not significantly correlated.
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