Key result
A single prophylactic dose of 10 mg intravenous ephedrine significantly reduced the incidence of hypotension during spinal anesthesia compared to crystalloid preload alone (23.33% vs 80.00%).
Why the study?
Does a single prophylactic dose of ephedrine 10 mg IV prevent hypotension in patients undergoing spinal anesthesia?
Does a single prophylactic dose of ephedrine 10 mg IV prevent hypotension in patients undergoing spinal anesthesia?
Absolute Event Rate: 23.33% vs 80%
p-value: p=<0.05
A single prophylactic 10 mg IV dose of ephedrine significantly reduces the incidence of hypotension during spinal anesthesia compared to crystalloid preload alone.
May reduce spinal hypotension risk; hypothesis-generating and should not change practice without RCTs.
The aim of the study was to assess the efficacy of single prophylactic dose (10mg) of ephedrine given to prevent hypotension in patients during spinal anesthesia. STUDY DESIGN: Semi experimental. Place and Duration of Study: This study was conducted at Anesthesia Department of our institution over a period of 6 months from June 2010 to November 2010. MATERIAL AND METHODS: Sixty patients, who were to be operated under spinal anesthesia, for lower abdominal general surgery, obstetric-gynecological and lower limb orthopedic surgery, were divided into two groups. Group I (n=30) received Ringer's lactate solution 15 ml/kg as preload and group II (n=30) received Ringer's lactate solution 15 ml/kg as preload along with single prophylactic dose of injection ephedrine 10 mg intravenously which was given after administering spinal anesthesia. Various parameters of the patients were recorded and the comparison was made between groups I and group II. Heart rate, systolic and diastolic blood pressures and oxygen saturation were monitored at 5 minutes interval till the completion of surgery. RESULTS: Out of 60 patients 36 were males and 24 were females. 37 patients belonged to American Society of Anesthesiologist (ASA)-1 and 23 patients belonged to ASA II. In group I the average age of the patients was 26.246.4 years while in group II it was 24.123.2 years. There were no significant statistical differences for age, weight and height of the patients between two groups. The changes in heart rate, systolic and diastolic blood pressures were compared between groups, after taking baseline readings, at 5 minutes interval till the end of surgery. The base line readings were not significantly different statistically but subsequent readings showed significantly low incidence of hypotension in group II as compared to group I. CONCLUSION: Administration of single prophylactic dose (10mg) of ephedrine prevents hypotension in patients during spinal anesthesia
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Tiwari et al. (2014) studied Hypotension during spinal anesthesia (n=60). Ephedrine vs. Ringer's lactate solution 15 ml/kg as preload alone was evaluated on Incidence of hypotension (p=<0.05). A single prophylactic dose of 10 mg intravenous ephedrine significantly reduced the incidence of hypotension during spinal anesthesia compared to crystalloid preload alone (23.33% vs 80.00%).
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