Key result
Autoantibodies against the heart conduction system were found in 20% of patients with chronic chagasic cardiopathy compared to 5% in non-chagasic cardiopathy and indeterminate chagasic subjects.
Why the study?
Are seric autoantibodies against the heart conduction system markers of chronic chagasic cardiopathy?
Population
85 subjects including 25 with chronic chagasic cardiopathy, 20 with non-chagasic cardiopathy, 20…
Comparison
Detection of seric autoantibodies against… vs Non-chagasic cardiopathy patients, indeterminate…
Design
Case-control
Authors
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Seric autoantibodies against the heart conduction system should not guide diagnosis of chronic chagasic cardiopathy; leaves open their role in larger prospective cohorts.
Case-Control (n=85)
Are seric autoantibodies against the heart conduction system markers of chronic chagasic cardiopathy?
Absolute Event Rate: 20% vs 5%
Seric autoantibodies against the heart conduction system are not reliable markers for chronic chagasic cardiopathy and do not correlate with conduction aberrations.
Arce-Fonseca et al. (2005) conducted a case-control in Chagas' disease (n=85). Chronic chagasic cardiopathy vs. Non-chagasic cardiopathy, indeterminate chagasic subjects, and healthy controls was evaluated on Presence of seric autoantibodies against AV node and sinus auricular node tissues. Autoantibodies against the heart conduction system were found in 20% of patients with chronic chagasic cardiopathy compared to 5% in non-chagasic cardiopathy and indeterminate chagasic subjects.
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