Why the study?
Does left ventricular mechanical dyssynchrony predict cardiovascular death in the general population?
Population
1,138 participants from the general population without atrial fibrillation and significant valvular disease.
Design
Cohort
Follow-up
median 11.1 years (interquartile range: 10.2-11.3 years)
Key result
Left ventricular mechanical dyssynchrony independently predicted cardiovascular death in the general population (HR 1.04 per 10-ms increase; 95% CI 1.01-1.06; P=0.004).
Authors
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May enhance risk stratification beyond standard scores; leaves open whether assessment should guide therapy in the general population.
Cohort (n=1,138)
Does left ventricular mechanical dyssynchrony predict cardiovascular death in the general population?
Hazard Ratio: 1.04 (95% CI 1.01–1.06)
p-value: p=0.004
Left ventricular mechanical dyssynchrony assessed by echocardiography provides incremental prognostic value for predicting cardiovascular death in the general population beyond established risk scores.
Modin et al. (2018) conducted a cohort in General population (n=1,138). Left ventricular mechanical dyssynchrony (LVMD) was evaluated on Cardiovascular death (CVD) (HR 1.04, 95% CI 1.01-1.06, p=0.004). Left ventricular mechanical dyssynchrony independently predicted cardiovascular death in the general population (HR 1.04 per 10-ms increase; 95% CI 1.01-1.06; P=0.004).