Key result
MRI-derived LV dyssynchrony predicts ~1% higher MACE risk per millisecond in asymptomatic women, but not men.
Why the study?
Does left ventricular mechanical dyssynchrony predict major adverse cardiovascular events in asymptomatic women and men?
Population
1392 asymptomatic participants in the Multi-Ethnic Study of Atherosclerosis with cardiac magnetic resonance…
Comparison
Left ventricular mechanical dyssynchrony… vs Lower dyssynchrony or continuous comparison
Design
Cohort
Follow-up
median 8.3 years
Authors
Loading...
CMR LV dyssynchrony was associated with MACE in asymptomatic women but not men; leaves open its incremental value for sex-specific risk stratification.
Cohort (n=1,392)
Yes
Does left ventricular mechanical dyssynchrony predict major adverse cardiovascular events in asymptomatic women and men?
Effect estimate: HR 1.01 per 1-ms increment
p-value: p=0.015
Left ventricular mechanical dyssynchrony detected by cardiac MRI is an independent predictor of major adverse cardiovascular events in asymptomatic women, but not in men.
Sharma et al. (2014) conducted a cohort in Asymptomatic population (n=1,392). Left ventricular mechanical dyssynchrony (SD-TPS) was evaluated on Major adverse cardiovascular events (myocardial infarction, heart failure, stroke, and death) (HR 1.01 per 1-ms increment, p=0.015). Greater left ventricular dyssynchrony determined by cardiac MRI predicted major adverse cardiovascular events in asymptomatic women (HR 1.01 per 1-ms increment, P=0.015) but not in men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: