Key result
Increasing age was associated with delayed time to peak strain (regression coefficient 0.37 ms/year; 95% CI 0.05-0.70; P=0.025) and greater myocardial dyssynchrony in asymptomatic individuals.
Why the study?
Are age, LV mass, and myocardial perfusion associated with myocardial dyssynchrony in asymptomatic individuals?
Population
1100 asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis
Design
Cross-sectional
Authors
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Age-associated dyssynchrony may mediate subclinical dysfunction; hypothesis-generating for longitudinal outcome studies.
Cross-Sectional (n=1,100)
Are age, LV mass, and myocardial perfusion associated with myocardial dyssynchrony in asymptomatic individuals?
Effect estimate: Regression coefficient 0.37 ms/year of age (95% CI 0.05 to 0.70)
p-value: p=0.025
Age, increased LV mass, and decreased myocardial perfusion are associated with delayed myocardial contraction and greater dyssynchrony in asymptomatic individuals, potentially mediating the link between age/LV hypertrophy and myocardial dysfunction.
Rosen et al. (2009) conducted a cross-sectional in Asymptomatic individuals (n=1,100). Increasing age was associated with delayed time to peak strain (regression coefficient 0.37 ms/year; 95% CI 0.05-0.70; P=0.025) and greater myocardial dyssynchrony in asymptomatic individuals.
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