Key result
Immunization of guinea-pigs with rabbit skeletal muscle myosin-beta induced experimental myocarditis characterized by perivascular lymphomononuclear aggregates, necrosis, and myocardial degeneration.
Immunization with rabbit skeletal muscle myosin-beta induces experimental myocarditis in guinea-pigs, suggesting an immune-complex-mediated pathogenesis.
Hypothesis-generating for immune myocarditis models; leaves open translation to human disease.
In guinea-pigs, myocarditis was induced under experimental conditions by immunizing the animals with rabbit skeletal muscle myosin-beta. The salient histopathological features were foci of perivascular lymphonononuclear aggregates, necrosis, and degeneration of myocardial cells. Antimyosin-beta antibodies in the immune complexes were demonstrated in the sera of the guinea-pigs. An immune-complex-mediated tissue-injury is proposed in the pathogenesis of myocarditis.
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V.V. Radhakrishnan (1996) studied Myocarditis. Immunization with rabbit skeletal muscle myosin-beta was evaluated on Histopathological features and presence of antimyosin-beta antibodies. Immunization of guinea-pigs with rabbit skeletal muscle myosin-beta induced experimental myocarditis characterized by perivascular lymphomononuclear aggregates, necrosis, and myocardial degeneration.
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