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May 14, 2015Memórias do Instituto Oswaldo CruzOpen Access

Prevention of congenital Chagas through treatment of girls and women of childbearing age

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Key result

Prior benznidazole treatment in women with Chagas disease resulted in zero observed cases of congenital transmission to their newborns.

Why the study?

Does benznidazole treatment prevent congenital transmission of Chagas disease in women with Chagas disease?

Population

Women with Chagas disease and their newborns

Design

Cohort

Authors

GMGuillermo MoscatelliChildren's HospitalSMSamanta MoroniChildren's HospitalFGFacundo García‐BournissenWestern University

Discussion

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Implication

Supports preconception benznidazole to avert congenital Chagas; observational data leaves open causal efficacy pending RCTs.

Structured PICO

Does benznidazole treatment prevent congenital transmission of Chagas disease in women with Chagas disease?

P
Population
Women with Chagas disease and their newborns
I
Intervention
Benznidazole treatment
O
Outcome
Congenital transmission of Chagas disease to newbornshard clinical

Treatment of women with Chagas disease with benznidazole prior to pregnancy may prevent congenital transmission to their infants.

Cite This Study

Moscatelli et al. (2015) studied this question. Prior benznidazole treatment in women with Chagas disease resulted in zero observed cases of congenital transmission to their newborns.

synapsesocial.com/papers/6a9ed38deb5d4db53b6f0cddhttps://doi.org/10.1590/0074-02760140347
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Congenital Chagas' Disease: Diagnostic and Clinical Aspects1995 · 215 citations
  2. 2Benznidazole Treatment of Chagasic Encephalitis in Pregnant Woman with AIDS2013 · 34 citations
  3. 3Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease2014 · 628 citations
  4. 4Analytical Performance of a Multiplex Real-Time PCR Assay Using TaqMan Probes for Quantification of Trypanosoma cruzi Satellite DNA in Blood Samples2013 · 265 citations
  5. 5Congenital Transmission of<i>Trypanosoma cruzi</i>Is Associated with Maternal Enhanced Parasitemia and Decreased Production of Interferon‐γ in Response to Parasite Antigens2004 · 118 citations