Why the study?
Does phenylephrine administration alter cardiac function in a murine model?
Does phenylephrine administration alter cardiac function in a murine model?
In a murine model, acute phenylephrine administration significantly decreased cardiac output, ejection fraction, and stroke volume despite increasing arterial pressure, suggesting direct negative effects on cardiac function.
Should not change phenylephrine use in patients; leaves open translation of negative cardiac effects to humans.
BACKGROUND: Phenylephrine (PE) is a alpha-adrenergic agent commonly administered by perfusion and anesthesia. It is important to identify the effect of PE, especially on cardiac function. This study was intended to show the effects of PE on cardiac function in the murine model via pressure-volume loops. METHODS: Six C57BL/6J twelve-week-old female mice were studied prior to and following PE administration at 50 microg/kg IV. In vivo pressure-volume loops were recorded at both time points. RESULTS: There was an expected increase in maximum arterial pressure by 30% (p < 0.001) and end-systolic pressure by 34% (p < 0.001). However, there was a decrease in cardiac output by 30% (p = 0.0006), ejection fraction by 36% (p = 0.0003) and stroke volume by 25% (p < 0.004). CONCLUSIONS: This study demonstrates that PE has an effect on cardiac function beyond increasing vascular resistance. The data suggest the negative effects of PE on cardiac function may be related to stimulation of cardiac alpha-adrenergic receptors.
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Dunaway et al. (2007) studied this question.
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