Application of molecular-secondary ion mass spectrometry for drug metabolism studies. (III). Analysis of metal containing drugs by SIMS and TLC/SIMS.

The mass spectra of metal containing nonvolatile drugs and related compounds; i.e. cisplatin (Pt), transplatin (Pt), nitroprusside (Fe), cyanocobalamin (Co), mercurochrome (Hg), and chlorophyll b (Mg), were measured by molecular-secondary ion mass spectrometry (SIMS) directly coupled with thin-layer chromatography (TLC).Characterisitic positive or negative quasi-molecular ions were obtained sensitively in each metal containing compound by the addition of most suitable liquid matrix.