Key result
The presence of chronic obstructive pulmonary disease in hypertensive patients significantly increased the risk of major adverse cardiovascular events (HR 3.29) compared to hypertension alone.
Why the study?
Essential hypertension and chronic obstructive pulmonary disease often coexist, but whether chronic obstructive pulmonary disease modifies the risk of cardiovascular events in hypertensives remained to be evaluated.
Does the presence of COPD increase the risk of major adverse cardiovascular events in hypertensive patients?
Cohort (n=1,728)
No
Does the presence of COPD increase the risk of major adverse cardiovascular events in hypertensive patients?
Hazard Ratio: 3.29 (95% CI 2.276–4.756)
Absolute Event Rate: 25.3% vs 5.9%
p-value: p=0.0001
The coexistence of mild-to-moderate COPD in hypertensive patients independently and significantly increases the risk of major adverse cardiovascular events, particularly stroke.
Warrants consideration in risk stratification for hypertensive patients; extends prior associations but remains hypothesis-generating without randomized data.
Essential hypertension and chronic obstructive pulmonary disease often coexist in the same patient. The aim of this study was to evaluate whether the addition of chronic obstructive pulmonary disease modifies the risk of cardiovascular events in hypertensives. We enrolled 1728 hypertensives. Study outcomes included fatal and non-fatal cardiovascular stroke and myocardial infarction, and cardiovascular death. During a mean follow-up of 57 months there were 205 major adverse cardiovascular events (2.47 per 100 pts/yr): cardiac (n117; 1.41 per 100 pts/yr) and cerebrovascular (n = 77; 0.93 per 100 pts/yr). In hypertensives with chronic obstructive pulmonary disease we observed a greater number of cardiovascular events than in hypertensives without respiratory disease (133 [5.55 per 100 pts/yr) vs 72 [1.22 per 100 pts/yr], respectively. The addition of chronic obstructive pulmonary disease to hypertension increased the incidence of total and non-fatal stroke of more than nine- (2.42 vs 0.32 per 100 pts/yr) and 11-fold (2.09 vs 0.22 per 100 pts/yr), respectively. The same trend was observed for total (2.88 vs 0.81 per 100 pts/yr) and non-fatal (2.67 vs 0.79 per 100 pts/y) myocardial infarction. The presence of chronic obstructive pulmonary disease in hypertensives significantly increases the risk of stroke, myocardial infarction and major adverse cardiovascular events.
No takes yet. Share an insight, caveat, or question.
Perticone et al. (2021) conducted a cohort in Essential hypertension (n=1,728). Chronic obstructive pulmonary disease (COPD) vs. Hypertension without COPD was evaluated on Major adverse cardiovascular events (MACE) (HR 3.290, 95% CI 2.276-4.756, p=0.0001). The presence of chronic obstructive pulmonary disease in hypertensive patients significantly increased the risk of major adverse cardiovascular events (HR 3.29) compared to hypertension alone.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: