Key result
Streptozotocin-induced diabetes decreased beta adrenoceptor binding sites by 25% in the atrioventricular node of rat hearts compared to controls.
Why the study?
Does streptozotocin-induced diabetes alter beta adrenoceptor subtypes in the atrioventricular node of rat hearts?
Does streptozotocin-induced diabetes alter beta adrenoceptor subtypes in the atrioventricular node of rat hearts?
A decrease in beta adrenoceptors, primarily the beta 1 subtype, in the atrioventricular node may play an important role in cardiac conduction disturbances observed in diabetic animals.
May link reduced AV nodal beta-adrenoceptors to diabetic conduction defects; hypothesis-generating for human relevance.
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Saito et al. (1991) studied Diabetes (n=10). Streptozotocin vs. Vehicle alone was evaluated on 125I-iodocyanopindolol binding sites in the atrioventricular node. Streptozotocin-induced diabetes decreased beta adrenoceptor binding sites by 25% in the atrioventricular node of rat hearts compared to controls.
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