Key result
Intravenous glycopyrrolate and atropine produced similar increases in maternal heart rate (mean 36 vs 35 beats/min) in full-term parturients, with no significant changes in fetal heart rate.
Why the study?
Does intravenous glycopyrrolate compared to atropine affect maternal and fetal heart rates and variability in normal full-term parturients in labor?
Does intravenous glycopyrrolate compared to atropine affect maternal and fetal heart rates and variability in normal full-term parturients in labor?
Answers are grounded in this paper and cite their sources.
Intravenous glycopyrrolate and atropine produce similar significant increases in maternal heart rate without affecting fetal heart rate or maternal blood pressure during labor.
This study compared the effects of intravenous atropine and glycopyrrolate on maternal and fetal heart rates and variability, maternal blood pressure, and uterine activity in 20 normal full-term parturients in labor. Group 1 (N = 10) received 0.005 mg/kg of glycopyrrolate, and group 2 (N = 20) received 0.01 mg/kg of atropine. There were no statistically significant changes in fetal heart rates or variability in either group. Uterine activity increased in a normal manner as labor progressed. Maternal heart rate increased significantly and essentially equally in all patients in both groups ranging from 15 to 78 beats/min and a mean (± SD) of 36 ± 16 in group 1 and from 15 to 65 beats/min with a mean of 35 ± 17 in group 2. There were no statistically significant changes in maternal blood pressure in either group.
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Abboud et al. (1983) studied Labor in normal full-term parturients (n=30). Glycopyrrolate vs. Atropine 0.01 mg/kg IV was evaluated on Maternal heart rate increase (beats/min). Intravenous glycopyrrolate and atropine produced similar increases in maternal heart rate (mean 36 vs 35 beats/min) in full-term parturients, with no significant changes in fetal heart rate.
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