Why the study?
Does intravenous glycopyrrolate compared to atropine affect heart rate and rhythm in anaesthetised patients?
Does intravenous glycopyrrolate compared to atropine affect heart rate and rhythm in anaesthetised patients?
Intravenous glycopyrrolate is twice as potent as atropine in increasing heart rate in anaesthetised patients, though both cause dose-dependent dysrhythmias.
May inform glycopyrrolate dosing for HR support in anaesthesia; leaves open comparative rhythm effects in larger trials.
The effects of glycopyrrolate in doses of 5, 10 and 15 microgram/kg and atropine 10, 20 and 30 microgram/kg on heat rate and rhythm was studied in anesthetised patients. Both drugs produced a dose-related increase in heart rate. Glycopyrrolate was approximately twice as potent as atropine in increasing heart rate. The average time taken to achieve peak effect was 2-6 and 3-7 minutes for atropine and glycopyrrolate respectively, and this was significantly different. The smallest doses of both drugs were generally associated with supraventricular dysrhythmias, whereas these were mainly ventricular following the highest dose of both drugs.
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Mirakhur et al. (1981) studied this question.
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