Why the study?
Does intravenous glycopyrrolate compared to atropine reduce the increase in heart rate during induction of anaesthesia in patients undergoing ECT?
Does intravenous glycopyrrolate compared to atropine reduce the increase in heart rate during induction of anaesthesia in patients undergoing ECT?
Glycopyrrolate causes less tachycardia than atropine when used for induction of anaesthesia in ECT, while providing similar antisialogogue and protective effects.
May favor glycopyrrolate to limit tachycardia in ECT induction; hypothesis-generating and should not yet change practice.
In unpremedicated patients presenting for general anaesthesia for electroconvulsive therapy (ECT), the use of atropine combined with methohexitone as an intravenous induction agent was found to produce a significantly greater increase in heart rate than glycopyrrolate in similar combination. There was no difference in the antisialogogue effect of the two drugs at the doses used, and both drugs provided similar protection against the effects of suxamethonium and ECT on heart rate.
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Dewar et al. (1983) studied this question.
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