Why the study?
Does intravenous glycopyrrolate compared to atropine reduce dysrhythmias and heart rate changes during induction of anaesthesia in unpremedicated patients?
Does intravenous glycopyrrolate compared to atropine reduce dysrhythmias and heart rate changes during induction of anaesthesia in unpremedicated patients?
Glycopyrrolate causes fewer dysrhythmias and less tachycardia than atropine during anesthesia induction, making it a preferable anticholinergic for patients with cardiovascular impairment.
Glycopyrrolate should be preferred over atropine to limit tachycardia and dysrhythmias during induction; extends RCT evidence supporting its use in patients with cardiovascular impairment.
Glycopyrrolate, 0.2 mg, or atropine, 0.6 mg, was administered intravenously together with methohexitone for the induction of anaesthesia in unpremedicated patients. The use of atropine, compared with glycopyrrolate, was associated with a greater rise in heart rate, a greater number of patients whose heart rates doubled, and a higher incidence of dysrhythmias. Glycopyrrolate is recommended for use as an intravenous anticholinergic agent, particularly in patients with cardiovascular impairment.
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J. GreenanMB (1984) studied this question.
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