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Summarize emerging clinical trials and experimental strategies aimed at preventing insulin-dependent diabetes mellitus in individuals identified as being at high risk.

March 1, 1998Diabetes/Metabolism Reviews

Prevention of insulin-dependent diabetes mellitus 1998

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PPPaolo PozzilliSt Bartholomew's Hospital

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Implication

Review reveals emerging preventive trials in susceptible populations, highlighting immune tolerance and dietary interventions to halt diabetes.

Key Points

Summarize emerging clinical trials and experimental strategies aimed at preventing insulin-dependent diabetes mellitus in individuals identified as being at high risk.
Reviewed ongoing randomized and nonrandomized prevention trials evaluating nicotinamide and prophylactic insulin administration.
Assessed pilot intervention trials testing immunotolerance induction and primary prevention through the removal of potential diabetogenic triggers in cow's milk.
Outcomes from the two primary multicenter prevention trials assessing nicotinamide and insulin remain pending, with definitive results expected after the turn of the century.
Early pilot trials demonstrate feasibility for inducing immunotolerance and establishing dietary modifications to support larger future multicenter prevention initiatives.

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Paolo Pozzilli (1998) studied this question.

synapsesocial.com/papers/6a9ede2e110f11dd1ebe36a7 https://doi.org/10.1002/(sici)1099-0895(199803)14:1<69::aid-dmr203>3.0.co;2-e

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Implication

Review reveals emerging preventive trials in susceptible populations, highlighting immune tolerance and dietary interventions to halt diabetes.

Prevention of insulin-dependent diabetes mellitus 1998

Discussion

Member takes

Implication

Key Points

Cite This Study

Prevention of insulin-dependent diabetes mellitus 1998

Discussion

Member takes

Implication

Key Points

Cite This Study

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