Key result
A 56-year-old man with liver cirrhosis secondary to non-alcoholic fatty liver disease presented with severe hypothyroidism, highlighting a potential clinical association between the two conditions.
Why the study?
Data supporting an association between primary hypothyroidism and NAFLD have been inconsistent, despite thyroid hormones being involved in body weight regulation, lipid metabolism, and insulin resistance.
Case Report (n=1)
This case report highlights a potential clinical association between severe hypothyroidism and non-alcoholic fatty liver disease (NAFLD) progressing to cirrhosis.
Data supporting an association between primary hypothyroidism and non-alcoholic fatty liver disease (NAFLD) is lacking. Thyroid hormones are totally involved in the regulation of body weight, lipid metabolism, and insulin resistance. Therefore, thyroid hormones may have a role in the pathogenesis of NAFLD and nonalcoholic steatohepatitis (NASH). The results of studies investigating the association between NAFLD and thyroid dysfunction have been inconsistent; many have provided data supporting the association, while a few others have refuted it. This report presents the case of a 56-year-old obese Hispanic man who was diagnosed with liver cirrhosis secondary to NAFLD and presented 3 months later with severe hypothyroidism. J Endocrinol Metab. 2020;10(2):45-48 doi: https://doi.org/10.14740/jem644
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Hazam et al. (2020) conducted a case report in Non-alcoholic fatty liver disease and hypothyroidism (n=1). Hypothyroidism was evaluated. A 56-year-old man with liver cirrhosis secondary to non-alcoholic fatty liver disease presented with severe hypothyroidism, highlighting a potential clinical association between the two conditions.
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