Key result
Type 2 diabetes was associated with significantly higher mean TSH levels (5.1 vs 3.3 mIU/L) and lower T3 and T4 levels compared to healthy controls, with approximately 25% of diabetic patients showing thyroid dysfunction.
Why the study?
Type 2 diabetes and thyroid dysfunction often coexist and complicate each other, motivating an assessment of thyroid dysfunction prevalence in patients with type 2 diabetes in the Malwa Region.
Is the prevalence of thyroid dysfunction higher in patients with type 2 diabetes compared to healthy controls?
Cross-Sectional (n=150)
No
Is the prevalence of thyroid dysfunction higher in patients with type 2 diabetes compared to healthy controls?
Absolute Event Rate: 5.1% vs 3.3%
p-value: p=0.001
About one in four patients with type 2 diabetes in this cohort had comorbid thyroid dysfunction, highlighting the potential need for routine thyroid screening in this population.
Supports higher thyroid dysfunction in type 2 diabetes; hypothesis-generating for screening and needs prospective validation.
Background: Diabetes mellitus, a leading cause of death worldwide, is the most common endocrine disorder. Type 2 Diabetes (T2D) and Thyroid Dysfunction (TD) often present together and complicate each other at many levels. Recent studies find out the prevalence of TD in T2D in Malwa Region. Objective of the purpose of this study was to find out the prevalence of TD in patients with T2D.Methods: A match cross-sectional study design was conducted at Department of Medicine, Sri Aurobindo Medical College, from March 2018 to April 2019. Source populations were all patients who live in Malwa Region, Indore. A total of 150 cases were enrolled in this study, 75 cases (TD in T2D) and 75 controls were taken into study.Results: There was no significant difference in age and body mass index (BMI) between groups. The average duration of diabetes was 7.76±5.57 years and mean Hemoglobin A1c (HBA1c) was 8.17±1.66%. Only 29(38.6%) of patients had HbA1c below 7%. There was significant difference (p=0.001) in HbA1c. Prevalence of TD in T2D was significantly more in females. Out of TD in T2D patients, sub-clinical hypothyroid was present in 14.6% hypothyroidism was present in 8% patients and sub-clinical hyperthyroidism and hyperthyroidism was present in 1.3% patients.Conclusions: This study reveals about one in four people living with T2D are suffering from TD in Malwa Region. TD is common in T2D patients and can produce significant metabolic disturbances.
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Vaidya et al. (2019) conducted a cross-sectional in Type 2 Diabetes and Thyroid Dysfunction (n=150). Type 2 Diabetes vs. Healthy controls without diabetes was evaluated on Mean TSH level (mIU/L) (p=0.001). Type 2 diabetes was associated with significantly higher mean TSH levels (5.1 vs 3.3 mIU/L) and lower T3 and T4 levels compared to healthy controls, with approximately 25% of diabetic patients showing thyroid dysfunction.
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