Key result
Gaussian modeling parameters of PPG pulses changed significantly across trimesters in healthy pregnant women, reflecting dynamic changes in the maternal cardiovascular system.
Why the study?
The study was conducted to depict changes in finger photoplethysmographic pulse during pregnancy in healthy women using Gaussian modeling.
Does Gaussian modeling of finger PPG pulses reflect changes in the maternal cardiovascular system during healthy pregnancy?
Cohort (n=70)
Does Gaussian modeling of finger PPG pulses reflect changes in the maternal cardiovascular system during healthy pregnancy?
Gaussian modeling of PPG pulses can non-invasively track maternal cardiovascular changes, such as cardiac output and peripheral vascular resistance, during healthy pregnancy.
May support non-invasive PPG monitoring of maternal hemodynamics in pregnancy; hypothesis-generating observational data requiring prospective validation.
We used Gaussian modeling to depict the changes in finger photoplethysmographic (PPG) pulse during pregnancy in healthy women. We enrolled 70 healthy pregnant women and recorded their PPG pulses in 11–13 gestational weeks, 20–22 gestational weeks, and 37–39 gestational weeks. Three independent positive Gaussian functions were utilized to decompose the pulses, and each Gaussian function extracted three key parameters: the peak amplitude ([Formula: see text]), the peak position ([Formula: see text]), and the half-width ([Formula: see text]). The method of ANOVA and post-hoc multiple comparisons of mathematical statistics were utilized to study the differences of these parameters between the three trimesters. We found that in the first trimester [Formula: see text] increased significantly ([Formula: see text]: [Formula: see text] versus [Formula: see text], [Formula: see text]). [Formula: see text] and [Formula: see text] increased in the first trimester ([Formula: see text]: [Formula: see text] versus [Formula: see text], [Formula: see text]; [Formula: see text]: [Formula: see text] versus [Formula: see text], [Formula: see text]), then decreased significantly ([Formula: see text]: [Formula: see text] versus [Formula: see text], [Formula: see text]: [Formula: see text] versus [Formula: see text], [Formula: see text]). [Formula: see text] is associated with cardiac output, and [Formula: see text] and [Formula: see text] are associated with peripheral vascular resistance. The results of this study were consistent with the conclusion that healthy pregnant women exhibited high flow state of the cardiovascular system and their peripheral vascular resistance decreased first and then gradually recovered during pregnancy. This study indicated that PPG pulse could also reflect the changes in the maternal cardiovascular system during pregnancy.
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Meng et al. (2021) conducted a cohort in Healthy pregnancy (n=70). Pregnancy progression vs. Between trimesters was evaluated on Changes in Gaussian modeling parameters of PPG pulse (peak amplitude, peak position, half-width). Gaussian modeling parameters of PPG pulses changed significantly across trimesters in healthy pregnant women, reflecting dynamic changes in the maternal cardiovascular system.
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