Key result
Host susceptibility factors, environmental factors, and T. cruzi genetic diversity are reviewed as potential mechanisms for the development of chronic chagasic cardiomyopathy.
This review highlights the role of host genetic susceptibility and pathologic features in the development of chronic chagasic cardiomyopathy following acute Trypanosoma cruzi infection.
Provides no immediate clinical guidance for Chagas cardiomyopathy; leaves open mechanistic roles of host susceptibility and parasite factors.
Chronic chagasic cardiomyopathy (CCC) is the main contributor to morbidity and mortality among individuals chronically infected with the protozoan parasite Trypanosoma cruzi. However, cardiomyopathy develops in fewer than one-third of these patients. Among the different mechanisms to explain this variability are environmental factors, T. cruzi genetic diversity, and host susceptibility. CCC is the culmination of a pathologic process with an onset during the acute infection phase. Previous studies of host genetic factors have been limited to a few candidate genes. This review describes the pathologic features of acute and chronic myocarditis and the host susceptibility factors that may contribute to the development of chagasic cardiomyopathy.
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Henao‐Martínez et al. (2012) conducted a review in Chronic chagasic cardiomyopathy. Host susceptibility factors was evaluated. Host susceptibility factors, environmental factors, and T. cruzi genetic diversity are reviewed as potential mechanisms for the development of chronic chagasic cardiomyopathy.
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