Pathological findings suggest chronic chagasic cardiomyopathy is multifactorial, driven by Trypanosoma cruzi presence and inadequate host immune response.
Supports multifactorial parasite-driven pathology in Chagas cardiomyopathy; hypothesis-generating and should not yet change practice.
This article tries to demonstrate by new pathological findings (with the use of immunohistochemical technique and confocal laser microscopy) that chronic chagasic cardiomyopathy is a result of multiple factors involving myocarditis, immunodepression, severe fibrosis and microvessels dilatation and that all of these alterations are probably directly related with the presence of Trypanosoma cruzi parasites in the host associated with inadequate immunological response of the host.
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Maria de Lourdes Higuchi (1999) studied this question.
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