Key result
Schizophrenia is linked to ~75% lower odds of post-NSTEMI angiography vs no mental disorder.
Why the study?
It was unknown how receipt of guideline-informed MI care compares by mental disorder and how the COVID-19 pandemic affected these associations.
Does a prior diagnosis of mental disorder reduce the receipt of guideline-informed care in adults hospitalized with myocardial infarction?
Cohort (n=210,120)
Yes
Does a prior diagnosis of mental disorder reduce the receipt of guideline-informed care in adults hospitalized with myocardial infarction?
Odds Ratio: 0.25 (95% CI 0.2–0.31)
Absolute Event Rate: 71% vs 86.5%
Patients with mental disorders, particularly schizophrenia, experience significant disparities in receiving guideline-directed acute myocardial infarction care, highlighting a critical need for targeted health equity interventions.
Patients with mental disorders may experience MI care gaps; leaves open whether targeted interventions can reduce NSTEMI angiography disparities.
OBJECTIVES: To compare receipt of guideline-informed myocardial infarction (MI) care by mental disorder and assess how the COVID-19 pandemic affected associations. DESIGN: A population-based cohort study using linked electronic health records. SETTING: England, November 2019 to February 2023. PARTICIPANTS: 131 075 adults with non-ST-elevation MI (NSTEMI) and 79 045 adults with ST-elevation MI (STEMI) were identified from the Myocardial Ischaemia National Audit Project, and their prior diagnoses of mental disorder were ascertained from linked hospitalisation and primary care records. OUTCOME MEASURES: We compared guideline-informed care standards for each of NSTEMI and STEMI between people with schizophrenia, bipolar disorder or depression versus those without any of these disorders. We used logistic regression to adjust for confounders and investigate differences over time. RESULTS: Mental disorder disparities were more evident for NSTEMI than STEMI. Following NSTEMI, people with a mental disorder had lower odds of angiography eligibility and receipt, cardiac ward admission and cardiac rehabilitation referral. ORs (95% CIs) ranged from 0.25 (0.20 to 0.31) for angiography receipt for schizophrenia to 0.92 (0.89 to 0.96) for cardiac ward admission for depression. Following STEMI, people with bipolar disorder were less likely to meet the 150 min call-to-balloon target (OR 0.72; 95% CI 0.55 to 0.93), and people with schizophrenia were less likely to receive rehabilitation referral (OR 0.38; 95% CI 0.23 to 0.61) or indicated secondary prevention medication (OR 0.46, 95% CI 0.27 to 0.77). There was no clear evidence that the COVID-19 pandemic affected disparities. CONCLUSIONS: People with a mental disorder are less likely to receive guideline-informed MI care, with disparities greatest following NSTEMI and for people with schizophrenia.
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Fleetwood et al. (2026) conducted a cohort in Myocardial infarction (NSTEMI and STEMI) (n=210,120). Mental disorder (schizophrenia, bipolar disorder, or depression) vs. No mental disorder was evaluated on Receipt of angiography following NSTEMI among eligible patients (schizophrenia vs no mental disorder) (OR 0.25, 95% CI 0.20 to 0.31). People with a mental disorder were less likely to receive guideline-informed MI care, with the greatest disparities seen in angiography receipt following NSTEMI for people with schizophrenia (OR 0.25).
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