Discovery of three cytochrome P450 monooxygenase prenyl cyclases that catalyze the final step of glyceollin biosynthesis in soybean

Glyceollins are isoflavonoid-derived metabolites produced by soybean that hold great promise in improving human and animal health. The recurrent use of antibiotics in animal production has led to the emergence of antibiotic resistance, which is causing a global challenge for public health and food systems. Owing to their broad-spectrum antimicrobial properties, glyceollins are being proposed to replace antibiotics in the swine industry to reduce antibiotic-resistant microorganisms in the food supply (Zavadil, 2020; Ika Irianti et al., 2023).