Key result
Human tissue valves (autografts or allografts) for pediatric aortic valve replacement yielded higher event-free survival at 2 years compared with mechanical prostheses (96% vs 67%; P<.05).
Why the study?
Does the use of human tissue valves (autografts/allografts) improve event-free and reoperation-free survival compared to mechanical prostheses in children undergoing aortic valve replacement?
Population
Children undergoing aortic valve replacement. Includes patients with Marfan's syndrome or unusable pulmonary…
Comparison
Human tissue valves vs Mechanical prostheses (n=26)
Design
Cohort
Follow-up
up to 3 years
Authors
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May support human tissue valves in pediatric AVR; hypothesis-generating and should not yet change practice.
Cohort (n=51)
Does the use of human tissue valves (autografts/allografts) improve event-free and reoperation-free survival compared to mechanical prostheses in children undergoing aortic valve replacement?
Absolute Event Rate: 96% vs 67%
p-value: p=<.05
In children requiring aortic valve replacement, the use of autografts or allografts significantly improves early event-free survival and reduces the need for reoperation compared to mechanical prostheses.
Lupinetti et al. (1997) conducted a cohort in Aortic valve replacement in children (n=51). Human tissue valves (autografts or allografts) vs. Mechanical prostheses was evaluated on Event-free survival at 2 years (p=<.05). Human tissue valves (autografts or allografts) for pediatric aortic valve replacement yielded higher event-free survival at 2 years compared with mechanical prostheses (96% vs 67%; P<.05).
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