Key result
Apnoeic oxygenation during halothane anaesthesia caused respiratory acidosis proportional to apnoea duration, increased blood pressure and pulse rate, and postoperative arterial desaturation.
Why the study?
What are the physiological and cardiovascular effects of apnoeic oxygenation during halothane anaesthesia?
Observational
What are the physiological and cardiovascular effects of apnoeic oxygenation during halothane anaesthesia?
Apnoeic oxygenation during halothane anaesthesia induces respiratory acidosis and sympathetic activation, leading to cardiovascular changes and ventricular extrasystoles.
Caution advised with apnoeic oxygenation under halothane; leaves open effects with modern agents and ventilation strategies.
SUMMARY The effect of apnoeic oxygenation during halothane anaesthesia has been studied. The results obtained are broadly in agreement with those reported by other workers. The extent of the acidosis is directly related to the duration of apnoea. Metabolic disturbance played only a small part in its development which is primarily respiratory in origin. Pulse rate, pulse pressure and blood pressure were all increased and there were associated ventricular extrasystoles. It is suggested that increased sympathetic activity due to the raised carbon dioxide tension in arterial blood is responsible. Desaturation of arterial blood was observed postoperatively, and it is suggested that this is due to a disturbance of the ventilation/perfusion ratio. ZUSAMMENFASSUNG Die Wirkung der Diffusionsatmung (←Apnoeic oxygenation→) während der Halothan‐Narkose wurde überprüft. Die erzielten Resultate stimmen im Grossen und Ganzen mit den bereits von anderen Autoren veröffentlichten überein. Das Ausmass der Azidose steht in direktem Verhältnis zur Dauer der Apnoe. Metabolische Storungen spielten nur eine geringe Rolle, sie sind vielmehr im wesentlichen respiratorischen Ursprungs. Pulsfrequenz, Pulsdruck und Blutdruck stiegen an und es traten gelegentliche ventrikuläre Extrasystolen auf. Man glaubt, dass die verstarkte Tätigkeit des Sympathikus, die wiederum durch den Anstieg der Kohlensäure‐Spannung im arteriellen Blut zustande kommt, dafür verantwortlich ist. Desaturation des arteriellen Blutes wurde postoperativ beobachtet und man nimmt an, dass dies durch eine Störung des Ventilations/Perfusions‐Verhältnisses bedingt ist.
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J. P. Payne (1962) conducted an observational in Halothane anaesthesia. Apnoeic oxygenation was evaluated on Acidosis and cardiovascular changes. Apnoeic oxygenation during halothane anaesthesia caused respiratory acidosis proportional to apnoea duration, increased blood pressure and pulse rate, and postoperative arterial desaturation.
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