Key result
Higher serum levels of macrophage inflammatory protein-1 alpha (MIP-1α) were significantly correlated with larger left atrial volume (r = 0.461, p < 0.001) in patients with atrial fibrillation.
Why the study?
Little is known about whether macrophage inflammatory protein-1 alpha (MIP-1α) can be used to predict left atrial remodeling, particularly in patients with AF.
Population
78 patients with a cardiac implantable electronic device for sick sinus syndrome
Comparison
MIP-1α levels and AF status vs LA remodeling
Design
Prospective observational cohort study
Follow-up
1 year
Authors
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MIP-1α may mark LA remodeling in AF; hypothesis-generating and should not yet change practice.
Observational (n=78)
No
Effect estimate: r = 0.461
p-value: p=<0.001
Higher serum levels of MIP-1α are significantly associated with larger left atrial volume and may serve as a biomarker for predicting left atrial remodeling in patients with atrial fibrillation.
Chen et al. (2021) conducted an observational in Atrial Fibrillation and Left Atrial Remodeling (n=78). Macrophage inflammatory protein-1 alpha (MIP-1α) vs. Lower MIP-1α levels / Patients without AF was evaluated on Left atrial volume (r = 0.461, p=<0.001). Higher serum levels of macrophage inflammatory protein-1 alpha (MIP-1α) were significantly correlated with larger left atrial volume (r = 0.461, p < 0.001) in patients with atrial fibrillation.
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