Why the study?
Does real-time RT-PCR accurately detect the t(X;18) translocation in paraffin-embedded and frozen synovial sarcoma specimens?
Does real-time RT-PCR accurately detect the t(X;18) translocation in paraffin-embedded and frozen synovial sarcoma specimens?
Real-time RT-PCR is a specific and sensitive technique for detecting the t(X;18) translocation in both frozen and paraffin-embedded synovial sarcoma samples.
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Enables molecular confirmation of synovial sarcoma on archival specimens; leaves open need for prospective validation in larger cohorts.
Hostein et al. (2002) studied this question.
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