Key result
In young healthy volunteers, carotid-femoral pulse wave velocity did not show significant circadian variation across four distinct periods of the day (P=0.85).
Why the study?
Does the time of day influence pulse wave velocity measurements in young healthy volunteers?
Observational (n=15)
Does the time of day influence pulse wave velocity measurements in young healthy volunteers?
p-value: p=0.85
Carotid-femoral pulse wave velocity does not exhibit significant circadian variation in young healthy volunteers, suggesting that measurements do not need to be standardized to a specific time of day.
Supports flexible PWV timing in young healthy volunteers; leaves open whether findings extend to older or diseased populations.
Arterial stiffness is an independent marker of cardiovascular events. Pulse wave velocity (PWV) is a validated method to detect arterial stiffness that can be influenced by several factors including age and blood pressure. However, it is not clear whether PWV could be influenced by circadian variations. In the present study, the authors measured blood pressure and carotid-femoral PWV measurements in 15 young healthy volunteers in 4 distinct periods: 8 am, noon, 4 pm, and 8 pm. No significant variations of systolic (P=.92), mean (P=.77), and diastolic (P=.66) blood pressure among 8 am (113±15, 84±8, 69±6 mm Hg), noon (114±13, 83±8, 68±6 mm Hg), 4 pm (114±13, 85±8, 70±7 mm Hg), and 8 pm (113±7, 83±10, 68±7 mm Hg), respectively, were observed. Similarly, carotid-femoral PWV did not change among the periods (8 am: 7.6 ± 1.4 m/s, noon: 7.4±1.1 m/s, 4 pm: 7.6±1.0 m/s, 8 pm, 7.6±1.3 m/s; P=.85). Considering all measurements, mean blood pressure significantly correlated with PWV (r=.31; P=.016). In young healthy volunteers, there is no significant circadian variation of carotid-femoral PWV. These findings support the concept that it does not appear mandatory to perform PWV measurements at exactly the same period of the day.
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Drager et al. (2010) conducted an observational in Healthy (n=15). Time of day (8 am, noon, 4 pm, 8 pm) vs. Comparison between different time periods was evaluated on Carotid-femoral pulse wave velocity (PWV) (p=0.85). In young healthy volunteers, carotid-femoral pulse wave velocity did not show significant circadian variation across four distinct periods of the day (P=0.85).
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