Key result
Serum CK and CK-B demonstrated the highest specificity (98%) with high sensitivity (97% for CK-B), whereas standard ECG had high specificity (96%) but low sensitivity (80%) for acute MI.
Why the study?
What is the sensitivity and specificity of different serum enzymes and standard ECG for diagnosing acute myocardial infarction in patients with suspected MI?
Cross-Sectional (n=463)
What is the sensitivity and specificity of different serum enzymes and standard ECG for diagnosing acute myocardial infarction in patients with suspected MI?
CK and CK-B subunit measurements provide superior diagnostic specificity for acute myocardial infarction compared to ASAT and heat stable LD, while maintaining high sensitivity.
Supports CK-B for high-specificity MI diagnosis in suspected cases; extends prior enzyme comparisons but leaves open validation against contemporary troponin assays.
Serum (S) enzyme activity of aspartate aminotransferase (ASAT, E.C. 2.6.1.1.), heat stable lactate dehydrogenase (LD, E.C. 1.1.1.27.), creatine kinase (CK, E.C. 2.7.3.2.) and CK-B subunit and the respective standard electrocardiograms (ECG) were compared in 463 patients with suspected acute myocardial infarction (MI) in order to evaluate sensitivity and specificity. Serum ASAT was analysed daily for 3 days, S-heat stable LD every 12 h for 48-108 h, S-CK and S-CK-B every 6 h for 48 h and ECG once daily for 3 days. All four enzymes had a high sensitivity, varying from 99% for LD to 97% for CK-B. The highest specificity was observed for CK-B and CK (98%) as compared with heat stable LD (91%) and ASAT (74%). Standard ECG showed a high specificity (96%) and a low sensitivity (80%).
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Å et al. (1985) conducted a cross-sectional in suspected acute myocardial infarction (n=463). Serum enzymes (ASAT, LD, CK, CK-B) and standard ECG was evaluated on Sensitivity and specificity for acute myocardial infarction. Serum CK and CK-B demonstrated the highest specificity (98%) with high sensitivity (97% for CK-B), whereas standard ECG had high specificity (96%) but low sensitivity (80%) for acute MI.
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