Type‐C particles in human tissues. II. Electron microscopic study of embryonic cultures infected with a murine leukemia virus

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Type‐C virus particles are synthesized by cells from a number of human embryonic cultures infected with the Rauscher murine leukemia virus (RV). These particles have the characteristic morphology of the murine leukemia viruses. In some cultures, type‐C particles were also observed budding into the cisternae of rough endoplasmic reticulum of a few cells. Virus particles in the vicinity of such cells were of “immature” type. In contrast, particles in the vicinity of those cells which did not synthesize intracisternal type‐C particle were of the “mature” type. It is not known if the “mature” intracisternal particles have the morphology of the “mature” extracellular type‐C particles.