Key result
A 20 mL dose of 0.25% bupivacaine for femoral nerve block provided equivalent analgesic efficacy to 0.50% bupivacaine after total knee replacement, with no significant difference in highest 24-hour VAS scores (2.95 vs 2.84).
Why the study?
The study aimed to compare the analgesic efficacy, side effect profile, and opioid consumption of femoral nerve blocks using different concentrations of bupivacaine (%0.5 vs %0.25) after total knee replacement.
Does 0.25% bupivacaine provide equivalent analgesia compared to 0.50% bupivacaine for femoral nerve block in patients undergoing total knee replacement?
Population
163 patients undergoing unilateral TKR surgery under spinal anesthesia
Comparison
%0.25 bupivacaine (20 mL) vs %0.50 bupivacaine (20 mL) for femoral block
Design
Single-center retrospective study
Follow-up
24 hours
Authors
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Supports 0.25% bupivacaine evaluation for femoral block post-TKR; leaves open confirmation of equivalence and safety in randomized trials.
Cohort (n=163)
No
Does 0.25% bupivacaine provide equivalent analgesia compared to 0.50% bupivacaine for femoral nerve block in patients undergoing total knee replacement?
Absolute Event Rate: 2.95% vs 2.84%
p-value: p=0.774
A 0.25% bupivacaine concentration for femoral nerve block provides equivalent postoperative analgesia to 0.50% bupivacaine after total knee replacement, potentially reducing the risk of systemic side effects and motor block.
Selvi et al. (2021) conducted a cohort in Total knee replacement (TKR) (n=163). 0.25% bupivacaine femoral nerve block vs. 0.50% bupivacaine femoral nerve block (20 mL) was evaluated on Highest visual analogue pain scale (VAS) score in the postoperative 24 hours (p=0.774). A 20 mL dose of 0.25% bupivacaine for femoral nerve block provided equivalent analgesic efficacy to 0.50% bupivacaine after total knee replacement, with no significant difference in highest 24-hour VAS scores (2.95 vs 2.84).
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