Key result
The St. Jude Trifecta bioprosthetic valve demonstrated significantly lower early post-operative mean transvalvular gradients (10.35 vs 14.5 mmHg) compared to the Carpentier-Edwards Perimount Magna valve.
Why the study?
Does the St. Jude Trifecta bioprosthetic valve improve early hemodynamic performance compared to the Carpentier-Edwards Perimount Magna valve in patients undergoing aortic valve replacement for severe aortic stenosis?
Cohort (n=100)
Single-blind
No
Does the St. Jude Trifecta bioprosthetic valve improve early hemodynamic performance compared to the Carpentier-Edwards Perimount Magna valve in patients undergoing aortic valve replacement for severe aortic stenosis?
Absolute Event Rate: 10.35% vs 14.5%
p-value: p=<0.001
The St. Jude Trifecta bioprosthetic valve demonstrates superior early hemodynamic performance with significantly lower transprosthetic gradients compared to the Carpentier-Edwards Perimount Magna valve.
May favor Trifecta for early hemodynamic optimization in AVR; leaves open durability and outcome impact without randomized data.
OBJECTIVE: Aim of this study was to compare the hemodynamic profiles of 2 aortic valve bioprostheses: the Carpentier Edwards Perimount Magna (CEPM) valve and the Trifecta valve. METHODS: 100 patients who underwent AVR for severe symptomatic AS between September 2011 and October 2012 were analyzed by means of standard trans-thoracic Doppler-echocardiography. RESULTS: Mean and peak gradients were significantly lower for the 21 mm Trifecta vs CEPM (11 +/- 4 vs 15 +/- 4 mmHg, and 20 +/- 6 vs 26 +/- 7 mmHg, respectively; all p < 0.05) and the 23 mm Trifecta vs CEPM (8 +/- 2 vs 14 +/- 4 mmHg, and 17 +/- 6 vs 25 +/- 9 mmHg; all p < 0.05). Effective orifice area tended to be slightly higher for the Trifecta valve. CONCLUSION: The new bioprosthetic valve Trifecta has an excellent hemodynamic profile, and lower trans-prosthesic gradients when compared to CEPM valve.
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Minardi et al. (2015) conducted a cohort in Severe symptomatic degenerative calcific aortic stenosis (n=100). St. Jude Trifecta valve vs. Carpentier-Edwards Perimount Magna valve was evaluated on Mean transvalvular gradient (mmHg) (p=<0.001). The St. Jude Trifecta bioprosthetic valve demonstrated significantly lower early post-operative mean transvalvular gradients (10.35 vs 14.5 mmHg) compared to the Carpentier-Edwards Perimount Magna valve.
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