Key result
Pre-intervention engagement of a temporal lobe reward motivation network during impulsive choices significantly predicted poorer responses to behavioral therapy in adolescent drug users.
Why the study?
Wide individual differences in responses to first-line behavioral therapies limit early intervention in adolescent drug misuse, highlighting the need to identify neural signatures that predict intervention response.
Do intertemporal decision-making-related brain states predict responses to behavioral therapy in adolescent alcohol and/or cannabis users?
Design
Longitudinal fMRI cohort study
Follow-up
Up to 6 months of follow-up
Authors
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May identify adolescents unlikely to respond to behavioral therapy; hypothesis-generating and requires prospective validation before clinical use.
Observational (n=30)
Do intertemporal decision-making-related brain states predict responses to behavioral therapy in adolescent alcohol and/or cannabis users?
Pre-intervention neural processing networks related to reward delay discounting can predict individual responses to behavioral therapy for adolescent drug misuse.
Elton et al. (2019) conducted an observational in Adolescent drug misuse (alcohol and/or cannabis) (n=30). Pre-intervention fMRI neural processing networks during a reward delay discounting task was evaluated on Intervention-related changes in drug misuse frequency (urinalysis and self-report). Pre-intervention engagement of a temporal lobe reward motivation network during impulsive choices significantly predicted poorer responses to behavioral therapy in adolescent drug users.
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