Key result
Translation of mouse kidney and submaxillary gland RNA in a cell-free system produced a renin precursor with a molecular weight of approximately 50,000, 10,000 daltons larger than mature renin.
The study provides the first direct evidence that mouse kidney renin is synthesized as a larger precursor molecule (preprorenin) of approximately 50,000 daltons.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications from this mouse model; leaves open preprorenin relevance in humans and warrants translational studies.
Translation of total poly(A)-containing RNA from mouse kidney in the wheat germ cell-free protein synthesis system resulted in the production of a form of renin with an apparent molecular weight of around 10,000 greater than that of mature, circulating renin.This is the first direct evidence indicating that kidney renin is synthesised in precursor form.Translation of total poly(A)-containing RNA from mouse sub~ maxillary gland, using the same cell-free system, also resulted in the production of a renin precursor, having the same molecular weight as the kidney species.
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Dykes et al. (1980) studied this question. In vitro translation of mouse kidney and submaxillary gland RNA was evaluated on Molecular weight of newly synthesized renin. Translation of mouse kidney and submaxillary gland RNA in a cell-free system produced a renin precursor with a molecular weight of approximately 50,000, 10,000 daltons larger than mature renin.
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